Myristicin

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Chemical Structure| 607-91-0 同义名 : Myristicine
CAS号 : 607-91-0
货号 : A455749
分子式 : C11H12O3
纯度 : 99%
分子量 : 192.21
MDL号 : MFCD00133549
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(546.28 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Myristicine act as a serotonin receptor antagonist, a weak monamine oxidase (MAO) inhibitor. Myristicine is the main component of nutmeg essential oil from Myristica fragrans Houtt[1]. Myristicin did not reduce the cell viability of RAW 264.7 mouse macrophages at concentrations of up to 50 μM. Myristicin significantly inhibited the production of calcium, nitric oxide (NO),interleukin (IL)-6, IL-10, interferon inducible protein-10, monocyte chemotactic protein(MCP)-1, MCP-3, granulocyte-macrophage colony-stimulating factor, macrophage inflammatory protein (MIP)-1α, MIP-1β, and leukemia inhibitory factor in dsRNA[polyinosinic-polycytidylic acid]-induced RAW 264.7 cells[2]. Myristicin inhibited cell proliferation and induced apoptosis in Huh-7 and HCCLM3 cells; suppressed cell migration and invasion ability, and increased E-cadherin expression and decreased N-cadherin expression, thereby inhibiting epithelial-mesenchymal transition (EMT). Myristicin decreased phosphorylated p-mTOR and p-AKT expression at the protein level[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.20mL

1.04mL

0.52mL

26.01mL

5.20mL

2.60mL

52.03mL

10.41mL

5.20mL
参考文献

[1]Kalbhen DA. Nutmeg as a narcotic. A contribution to the chemistry and pharmacology of nutmeg (Myristica fragrans). Angew Chem Int Ed Engl. 1971 Jun;10(6):370-4

[2]Lee JY, Park W. Anti-inflammatory effect of myristicin on RAW 264.7 macrophages stimulated with polyinosinic-polycytidylic acid. Molecules. 2011;16(8):7132-42

[3]Bao H, Muge Q. Anticancer effect of myristicin on hepatic carcinoma and related molecular mechanism. Pharm Biol. 2021 Dec;59(1):1126-1132