产品说明书

Trichlormethiazide

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Chemical Structure| 133-67-5 同义名 : -
CAS号 : 133-67-5
货号 : A451003
分子式 : C8H8Cl3N3O4S2
纯度 : 98%
分子量 : 380.656
MDL号 : MFCD00057315
存储条件：

粉末 Keep in dark place,Inert atmosphere,Room temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 145 mg/mL(380.92 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Trichlormethiazide is a thiazide diuretic with properties similar to those of hydrochlorothiazide.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT00246519 Hypertension Phase 4 Completed - United States, Florida ... 展开 >> University of Florida Department of Community Health and Family Medicine Gainesville, Florida, United States, 32610 United States, Georgia Emory University Atlanta, Georgia, United States, 30322 United States, Minnesota Mayo Clinic Rochester, Minnesota, United States, 55905 收起 <<
NCT02151877 Ischemia/Reperfusion Injury Af... 展开 >>ter Neonatal Cardiac Surgery Inflammatory Reaction After Neonatal Cardiac Surgery 收起 << Not Applicable Completed - United States, Illinois ... 展开 >> Advocate Children's Hospital Oak Lawn, Illinois, United States, 60453 收起 <<
NCT00246519 - Completed - -
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.63mL

0.53mL

0.26mL

13.14mL

2.63mL

1.31mL

26.27mL

5.25mL

2.63mL
参考文献

[1]Ushigome E, Matsumoto S, et al. Olmesartan with azelnidipine versus with trichlormethiazide on home blood pressure variability in patients with type II diabetes mellitus. J Am Soc Hypertens. 2017 Mar;11(3):140-147.

[2]Schulze S, Reinhardt S, et al. Identification of trichlormethiazide as a Mdr1a/b gene expression enhancer via a dual secretion-based promoter assay. Pharmacol Res Perspect. 2015 Feb;3(1):e00109.