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SMANT hydrochloride

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Chemical Structure| 1177600-74-6 同义名 : -
CAS号 : 1177600-74-6
货号 : A450950
分子式 : C16H24BrClN2O
纯度 : 97%
分子量 : 375.732
MDL号 : -
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 85 mg/mL(226.23 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 SMANT hydrochloride is a Smoothened (Smo) signalling inhibitor. SMANT hydrochloride inhibited Hh-induced Smo accumulation at the primary cilium in NIH/3T3 cells at a concentration of less than 10 μM (IC50=1.1 μM). SMANT hydrochloride equivalently inhibited the activities of Smo and SmoM2, and blocked the SAG in glial. SMANT hydrochloride inhibited Shh-induced proliferation of cerebellar granule cell neural progenitors (CGNP) (isolated from Ptch1+/- neonates)[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.66mL

0.53mL

0.27mL

13.31mL

2.66mL

1.33mL

26.61mL

5.32mL

2.66mL
参考文献

[1]Wang Y, et al. Selective identification of hedgehog pathway antagonists by direct analysis of smoothened ciliary translocation. ACS Chem Biol. 2012 Jun 15;7(6):1040-8.