产品说明书

Omeprazole

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Chemical Structure| 73590-58-6 同义名 : 奥美拉挫 ;H 16868;OMEP;OMZ;OMP
CAS号 : 73590-58-6
货号 : A449839
分子式 : C17H19N3O3S
纯度 : 98%
分子量 : 345.42
MDL号 : MFCD00083192
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(303.98 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

2% DMSO+30% PEG 300+water 5 mg/mL

生物活性
靶点

  • Proton Pump
描述 Omeprazole (H 16868), a proton pump inhibitor (PPI), is employed in managing acid-related gastrointestinal conditions. It exhibits competitive inhibition of the CYP2C19 enzyme with a Ki ranging between 2 and 6 μM[1]. Additionally, omeprazole acts as an inhibitor against both Gram-positive and Gram-negative bacteria[2]. Omeprazole also functions as a potent inhibitor of neutral sphingomyelinase (N-SMase), a brain penetrant enzyme involved in exosome regulation[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.90mL

0.58mL

0.29mL

14.48mL

2.90mL

1.45mL

28.95mL

5.79mL

2.90mL
参考文献

[1]Li XQ, et al. Comparison of inhibitory effects of the proton pump-inhibiting drugs omeprazole, esomeprazole, lansoprazole, pantoprazole, and rabeprazole on human cytochrome P450 activities. Drug Metab Dispos. 2004 Aug;32(8):821-7.

[2]Jonkers D, et al. Omeprazole inhibits growth of gram-positive and gram-negative bacteria including Helicobacter pylori in vitro. J Antimicrob Chemother. 1996 Jan;37(1):145-50.

[3]Huarui Zhang, et al. Advances in the discovery of exosome inhibitors in cancer. J Enzyme Inhib Med Chem. 2020 Dec;35(1):1322-1330.