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Genz-123346

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Chemical Structure| 943344-58-9 同义名 : -
CAS号 : 943344-58-9
货号 : A448924
分子式 : C52H82N4O14
纯度 : 99+%
分子量 : 987.226
MDL号 : -
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 Genz-123346 is an inhibitor of GL1 synthase that blocks the conversion of ceramide to GL1 and its IC50 for GM1 inhibition is 14 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.01mL

0.20mL

0.10mL

5.06mL

1.01mL

0.51mL

10.13mL

2.03mL

1.01mL
参考文献

[1]Chai L, McLaren RP, et al. The chemosensitizing activity of inhibitors of glucosylceramide synthase is mediated primarily through modulation of P-gp function. Int J Oncol. 2011 Mar;38(3):701-11.

[2]Zhao H, Przybylska M, et al. Inhibiting glycosphingolipid synthesis improves glycemic control and insulin sensitivity in animal models of type 2 diabetes. Diabetes. 2007 May;56(5):1210-8.