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Geniposidic acid

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Chemical Structure| 27741-01-1 同义名 : 京尼平甙酸
CAS号 : 27741-01-1
货号 : A447520
分子式 : C16H22O10
纯度 : 98%
分子量 : 374.34
MDL号 : MFCD00210294
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(280.49 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Geniposidic acid (GA) is an iridoid glucoside isolated from Gardeniae jasminoides Ellis (Rubiaceae) that has long been used to treat inflammation, jaundice and hepatic disorders. Geniposidic acid alleviates GalN/LPS-induced liver injury by enhancing antioxidative defense system and reducing apoptotic signaling pathways[3]. GPA (Geniposidic Acid) treatment significantly improved the spatial learning and memory abilities and also decreased cerebral amyloid-β deposition in APP/PS1 mice[4]. The relative IC50 of geniposidic acid on SMC inhibition was 87.73 μg/ml. Geniposide acid also showed promotion effect on ECs proliferation, and the related ED50 of geniposidic acid was 86.05 μg/ml. Besides, only 50 and 100 μg/ml geniposidic acid showed obvious inhibition on SMC migration from the upper chamber. The effects of geniposidic acid on protecting vascular endothelium and reversing plaque formation in an atherosclerotic model were demonstrated[5]. Geniposidic acid could improve bile acid hepatointestinal circulation and play a liver protection and cholagogu role in cholestasis rats induced by ANIT. The mechanism may be that Geniposidic acid activated FXR by regulating Sirt1, a key regulator of oxidative stress injury,and then the activated FXR could regulate protein of bile acid hepato-enteric circulation[6].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.67mL

0.53mL

0.27mL

13.36mL

2.67mL

1.34mL

26.71mL

5.34mL

2.67mL
参考文献

[1]Gao Y, Chen ZY, et al. Anti-atherosclerotic effect of geniposidic acid in a rabbit model and related cellular mechanisms. Pharm Biol. 2015 Feb;53(2):280-5.

[2]Hsu HY, Yang JJ, et al. Comparisons of geniposidic acid and geniposide on antitumor and radioprotection after sublethal irradiation. Cancer Lett. 1997 Feb 26;113(1-2):31-7.

[3]Kim SJ, Kim KM, Park J, Kwak JH, Kim YS, Lee SM. Geniposidic acid protects against D-galactosamine and lipopolysaccharide-induced hepatic failure in mice. J Ethnopharmacol. 2013 Mar 7;146(1):271-7

[4]Zhou Z, Hou J, Mo Y, Ren M, Yang G, Qu Z, Hu Y. Geniposidic acid ameliorates spatial learning and memory deficits and alleviates neuroinflammation via inhibiting HMGB-1 and downregulating TLR4/2 signaling pathway in APP/PS1 mice. Eur J Pharmacol. 2020 Feb 15;869:172857

[5]Gao Y, Chen ZY, Liang X, Xie C, Chen YF. Anti-atherosclerotic effect of geniposidic acid in a rabbit model and related cellular mechanisms. Pharm Biol. 2015 Feb;53(2):280-5

[6]Chen H, Li J, Hu L, Zhao W, Yu H, Liu HZ, Ma ST. [Effect of geniposidic acid on hepato-enteric circulation in cholestasis rats through Sirt1-FXR signaling pathway]. Zhongguo Zhong Yao Za Zhi. 2019 Feb;44(4):787-795. Chinese