Lapatinib ditosylate monohydrate

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Chemical Structure| 388082-78-8 同义名 : 二甲苯磺酸拉帕替尼 一水合物 ;GW2016 ditosylate monohydrate;GW572016 ditosylate monohydrate;Lapatinib tosilate hydrate;Lapatinib tosilate;Lapatinib ditoluenesulfonate monohydrate
CAS号 : 388082-78-8
货号 : A447246
分子式 : C43H44ClFN4O11S3
纯度 : 98%
分子量 : 943.476
MDL号 : MFCD18904381
存储条件：

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(53 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Lapatinib ditosylate monohydrate (GW572016 ditosylate monohydrate) is a potent inhibitor targeting the tyrosine kinase domains of ErbB-2 and EGFR, demonstrating IC50 values of 9.8 nM and 10.2 nM against purified ErbB-2 and EGFR respectively[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.06mL

0.21mL

0.11mL

5.30mL

1.06mL

0.53mL

10.60mL

2.12mL

1.06mL
参考文献

[1]Rusnak DW, et al. The effects of the novel, reversible epidermal growth factor receptor/ErbB-2 tyrosine kinase inhibitor, GW2016, on the growth of human normal and tumor-derived cell lines in vitro and in vivo. Mol Cancer Ther. 2001 Dec;1(2):85-94.