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Fasentin

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Chemical Structure| 392721-37-8 同义名 : -
CAS号 : 392721-37-8
货号 : A444978
分子式 : C11H9ClF3NO2
纯度 : 99%+
分子量 : 279.643
MDL号 : MFCD01001285
存储条件：

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(375.48 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Fasentin is an effective inhibitor of glucose uptake, targeting GLUT-1/GLUT-4 transport proteins. It preferentially inhibits GLUT4 over GLUT1, with an IC50 value of 68 μM. Fasentin acts as a sensitizer to FAS, making cells more susceptible to FAS-induced cell death. It also serves as a sensitizer for the TNF apoptosis-inducing ligand. Fasentin can block glucose uptake in cancer cell lines and exhibits anti-angiogenic activity[1][2][3]. When cells are treated with Fasentin at concentrations ranging from 25-100 μM for 16-24 hours, it induces a cell cycle arrest at the G0/G1 phase and reduces the number of cells in the S phase in a dose-dependent manner[1]. At a concentration of 50 μM, a 16-hour treatment with Fasentin alters the expression of genes associated with glucose deprivation, such as AspSyn and PCK-2. Furthermore, pre-treating cells for 1 hour at concentrations of 15, 30, and 80 μM, Fasentin can induce glucose deprivation and partially block glucose uptake in PPC-1, DU145, and U937 cells[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.58mL

0.72mL

0.36mL

17.88mL

3.58mL

1.79mL

35.76mL

7.15mL

3.58mL
参考文献

[1]Mª Carmen Ocaña, et al. Fasentin diminishes endothelial cell proliferation, differentiation and invasion in a glucose metabolism-independent manner. Sci Rep. 2020 Apr 9;10(1):6132.

[2]Tabitha E Wood, et al. A novel inhibitor of glucose uptake sensitizes cells to FAS-induced cell death. Mol Cancer Ther. 2008 Nov;7(11):3546-55.

[3]Qin Wu, et al. GLUT1 inhibition blocks growth of RB1-positive triple negative breast cancer. Nat Commun. 2020 Aug 21;11(1):4205.