(±)-Zanubrutinib
产品说明书
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同义名 : | (±)-BGB-3111 |
| CAS号 : | 1633350-06-7 | |
| 货号 : | A444177 | |
| 分子式 : | C27H29N5O3 | |
| 纯度 : | 99%+ | |
| 分子量 : | 471.551 | |
| MDL号 : | MFCD30738015 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 30 mg/mL(63.62 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO 无水乙醇: 8 mg/mL(16.97 mM)，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 |
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| 动物实验配方： |
| 生物活性 | |||
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| 描述 | (±)-Zanubrutinib, also known as (±)-BGB-3111, is an efficacious, selective, oral Btk inhibitor that exhibits nanomolar-level Btk inhibitory activity. In various MCL and DLBCL cell lines, (±)-Zanubrutinib inhibits BCR-triggered autophosphorylation of Btk, blocks downstream PLC-γ2 signaling, and effectively suppresses cell proliferation. Compared to PCI-32765, (±)-Zanubrutinib demonstrates more restricted off-target activity against a panel of kinases, including ITK[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.12mL 0.42mL 0.21mL |
10.60mL 2.12mL 1.06mL |
21.21mL 4.24mL 2.12mL |
| 参考文献 |
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