产品说明书
Perospirone HCl
 |
同义名 : | SM-9018;Perospirone hydrochloride;SM-9018 hydrochloride |
| CAS号 : | 129273-38-7 | |
| 货号 : | A442922 | |
| 分子式 : | C23H31ClN4O2S | |
| 纯度 : | 98+% | |
| 分子量 : | 463.036 | |
| MDL号 : | MFCD07771999 | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(259.16 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 靶点 |
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| 描述 | In CHO cells expressing human 5-HT1A receptors, perospirone shows a high affinity (Ki = 0.72 nM), and exhibits partial agonistic efficacy. Perospirone changes epigenetic profiles of neural genes. It can cause DNA methylation changes in cell cultures. Perospirone is an inhibitor of Pgp which interferes directly and indirectly with the function of Pgp. The inhibition of Pgp by perospirone may cause clinically significant drug-drug interactions, especially in the tissue in which it accumulated. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.16mL 0.43mL 0.22mL |
10.80mL 2.16mL 1.08mL |
21.60mL 4.32mL 2.16mL |
