产品说明书

Skimmin

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Chemical Structure| 93-39-0 同义名 : Umbelliferone glucoside
CAS号 : 93-39-0
货号 : A442876
分子式 : C15H16O8
纯度 : 98%
分子量 : 324.283
MDL号 : MFCD00017710
存储条件：

粉末 Keep in dark place,Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(323.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Skimmin, a natural product isolated and purified from the herbs of Hydrangea paniculata with anti-inflammatory activity, can significantly improve renal function and suppress the IgG deposition as well as the development of glomerular lesions in a rat model of membranous glomerulonephritis, suppress diabetic nephropathy in rats effectively, and may slow down the renal fibrosis by regulating TGF-β1 signal pathway, and show cytotoxic effect on CAOV-4 cell line, with an IC50 of 70.03 ug/mL.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.08mL

0.62mL

0.31mL

15.42mL

3.08mL

1.54mL

30.84mL

6.17mL

3.08mL
参考文献

[1]Zhang S, Xin H, et al. Skimmin, a Coumarin from Hydrangea paniculata, Slows down the Progression of Membranous Glomerulonephritis by Anti-Inflammatory Effects and Inhibiting Immune Complex Deposition. Evid Based Complement Alternat Med. 2013;2013:819296.

[2]Zhang S, Yang J, et al. Skimmin, a coumarin, suppresses the streptozotocin-induced diabetic nephropathy in wistar rats. Eur J Pharmacol. 2012 Oct 5;692(1-3):78-83.