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Dimethylcurcumin

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Chemical Structure| 52328-98-0 同义名 : 二甲基姜黄素 ;ASC-J9;GO-Y025
CAS号 : 52328-98-0
货号 : A442284
分子式 : C23H24O6
纯度 : 98%+
分子量 : 396.433
MDL号 : MFCD12912341
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(126.12 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Dimethylcurcumin (ASC-J9) induces dose-dependent degradation of fAR and AR3 in various human PCa cells. Moreover, Dimethylcurcumin (ASC-J9) effectively represses AR-targeted genes in CWR22Rv1-fARKD cells. Treatment with Dimethylcurcumin (ASC-J9) at concentrations of 5 or 10 µM significantly inhibits DHT-induced cell proliferation in all three PCa cell lines. Additionally, Dimethylcurcumin (ASC-J9) inhibits AR-targeted genes and cell proliferation by degrading fAR and ectopic AR3 in C81 and C4-2 cells [1]. Dimethylcurcumin (ASC-J9) selectively facilitates AR degradation by disrupting the interaction between AR and AR coregulators. ASC-J9 diminishes the aggregation of AR-112Q in cells. Furthermore, Dimethylcurcumin (ASC-J9) inhibits the aggregation of AR-112Q in SBMA PC12/AR-112Q cells [2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.52mL

0.50mL

0.25mL

12.61mL

2.52mL

1.26mL

25.22mL

5.04mL

2.52mL
参考文献

[1]Yamashita S, et al. ASC-J9 suppresses castration-resistant prostate cancer growth through degradation of full-length and splice variant androgen receptors. Neoplasia. 2012 Jan;14(1):74-83.

[2]Yang Z, et al. ASC-J9 ameliorates spinal and bulbar muscular atrophy phenotype via degradation of androgen receptor. Nat Med. 2007 Mar;13(3):348-53.

[3]Lee SO, et al. New therapy targeting differential androgen receptor signaling in prostate cancer stem/progenitor vs non-stem/progenitor cells. J Mol Cell Biol. 2012 Jul 24.