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PF-CBP1 HCl

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Chemical Structure| 2070014-93-4 同义名 : PF-CBP1 hydrochloride
CAS号 : 2070014-93-4
货号 : A441088
分子式 : C29H37ClN4O3
纯度 : 97%
分子量 : 525.08
MDL号 : MFCD29924742
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(199.97 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • p300/CBP

    CREBBP, IC50:125nM

    p300/CBP, IC50:363nM
描述 PF-CBP1 hydrochloride is a highly selective inhibitor of the bromodomain of CREB-binding protein (CREBBP).It inhibits CREBBP and p300 bromodomains with IC50 of 125 and 363 nM respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.52mL

1.90mL

0.95mL

19.04mL

3.81mL

1.90mL
参考文献

[1]Chekler EL, Pellegrino JA, et al. Transcriptional Profiling of a Selective CREB Binding Protein Bromodomain Inhibitor Highlights Therapeutic Opportunities. Chem Biol. 2015 Dec 17;22(12):1588-96.