产品说明书
CPI-1189
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同义名 : | REN 1654;REN 1189 |
| CAS号 : | 183619-38-7 | |
| 货号 : | A439031 | |
| 分子式 : | C13H18N2O2 | |
| 纯度 : | 97% | |
| 分子量 : | 234.294 | |
| MDL号 : | MFCD00774476 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(448.15 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | CPI-1189, an oral inhibitor of TNF-α release, also impedes the phosphorylation of p38. It has the capability to inhibit apoptosis and is utilized in research related to HIV and neurological diseases[1][2][3][4][5]. CPI-1189, at a concentration of 100 nM and a duration of 1 hour, can effectively prevent oxidative damage and neuronal cell death in SH-SY5Y cells induced by Oxygen glucose deprivation (OGD)/re-oxygenation (OGDR)[3]. CPI-1189, at a concentration of 10 nM and over a period of 2 hours, inhibits the phosphorylation of P38-mitogen-activated protein kinase induced by interleukin1β[4]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
4.27mL 0.85mL 0.43mL |
21.34mL 4.27mL 2.13mL |
42.68mL 8.54mL 4.27mL |
| 参考文献 |
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[1]Müller T. CPI-1189. Centaur. Curr Opin Investig Drugs. 2002 Dec;3(12):1763-7. |