产品说明书
Lincomycin HCl Monohydrate
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同义名 : | 林可霉素 ;Lincomycin Hydrochloride Monohydrate |
| CAS号 : | 7179-49-9 | |
| 货号 : | A437431 | |
| 分子式 : | C18H37ClN2O7S | |
| 纯度 : | Lincomycin B+Lincomycin HCL 96.0~102.0% | |
| 分子量 : | 461.01 | |
| MDL号 : | MFCD00167245 | |
| 存储条件： |
粉末 Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(227.76 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 50 mg/mL(108.46 mM)，配合低频超声助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Lincomycin HCl H2O is a lincosamide antibiotics used in clinical practice. It is bacteriostatic and inhibit protein synthesis in sensitive bacteria. It may even be bactericidal at the higher concentrations that can be reached in vivo[2]. Lincomycin and its derivatives are antibiotics exhibiting biological activity against Gram-positive bacteria. The semi-synthetic chlorinated lincomycin derivative is used in clinical practice[3]. Peak plasma level of lincomycin (71.8 ± 1.83 μg/mL) was observed at 1 min as expected by IV route. The elimination half-life and MRT of lincomycin were short (3.30 ± 0.08 and 4.32 ± 0.11 h, respectively). Lincomycin 10 mg/kg IV at 12-h interval would be sufficient to maintain T > MIC above 60 % for bacteria with minimum inhibitory concentrations (MIC) values ≤1.6 μg/mL. Lincomycin may be an appropriate antibacterial in buffalo species for gram-positive and anaerobic bacterial pathogens susceptible to lincomycin[4]. The place of lincomycin in therapeutics seems to be principally in the treatment of chronic osteomyelitis and, in patients allergic to the penicillins, in the treatment of staphylococcal, respiratory and other infections for which penicillin is usually employed[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.17mL 0.43mL 0.22mL |
10.85mL 2.17mL 1.08mL |
21.69mL 4.34mL 2.17mL |
| 参考文献 |
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[5]Duncan IB, Jeans B. Lincomycin in hospital practice. Can Med Assoc J. 1965;93(13):685‐691 |