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PD173955

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Chemical Structure| 260415-63-2 同义名 : -
CAS号 : 260415-63-2
货号 : A436930
分子式 : C21H16Cl2N4OS
纯度 : 99%+
分子量 : 443.349
MDL号 : MFCD16038305
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 9 mg/mL(20.3 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Bcr-Abl

    Bcr-Abl, IC50:1 nM-2 nM
描述 PD173955 is an src family-selective tyrosine kinase inhibitor with IC50 of ~22 nM for Src, Yes and Abl kinase and is less potent for FGFRα and no activity on InsR and PKC.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.26mL

0.45mL

0.23mL

11.28mL

2.26mL

1.13mL

22.56mL

4.51mL

2.26mL
参考文献

[1]Wisniewski D, Lambek CL, et al. Characterization of potent inhibitors of the Bcr-Abl and the c-kit receptor tyrosine kinases. Cancer Res. 2002 Aug 1;62(15):4244-55.

[2]Moasser MM, Srethapakdi M, et al. Inhibition of Src kinases by a selective tyrosine kinase inhibitor causes mitotic arrest. Cancer Res. 1999 Dec 15;59(24):6145-52.