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Humantenmine

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Chemical Structure| 82354-38-9 同义名 : Gelsenicine
CAS号 : 82354-38-9
货号 : A436430
分子式 : C19H22N2O3
纯度 : 98+%
分子量 : 326.39
MDL号 : MFCD20260333
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(321.7 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Humantenmine is a natural toxic compound isolated and purified from the roots of Gelsemium elegans with potential inhibition of several CYP450 enzyme activities.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.06mL

0.61mL

0.31mL

15.32mL

3.06mL

1.53mL

30.64mL

6.13mL

3.06mL
参考文献

[1]Wang Y, Wu S, et al. Inhibitory effects of cytochrome P450 enzymes CYP1A2, CYP2A6, CYP2E1 and CYP3A4 by extracts and alkaloids of Gelsemium elegans roots. J Ethnopharmacol. 2015 May 26;166:66-73.

[2]Li Y, Zeng RJ, et al. Ultrasound/microwave-assisted extraction and comparative analysis of bioactive/toxic indole alkaloids in different medicinal parts of Gelsemium elegans Benth by ultra-high performance liquid chromatography with MS/MS. J Sep Sci. 2014 Feb;37(3):308-13.