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PEAQX

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Chemical Structure| 459836-30-7 同义名 : NVP-AAM077;AAM 007;(1RS,1’S)-PEAQX
CAS号 : 459836-30-7
货号 : A432274
分子式 : C17H17BrN3O5P
纯度 : 98%
分子量 : 454.212
MDL号 : MFCD16628139
存储条件：

粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 PEAQX is a potent and orally active NMDA antagonist with a 15-fold preference for human NMDA receptors with the 1A/2A (IC50=270 nM), rather than 1A/2B(29,600 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.20mL

0.44mL

0.22mL

11.01mL

2.20mL

1.10mL

22.02mL

4.40mL

2.20mL
参考文献

[1]Anastasio NC, Xia Y, et al. Differential role of N-methyl-D-aspartate receptor subunits 2A and 2B in mediating phencyclidine-induced perinatal neuronal apoptosis and behavioral deficits. Neuroscience. 2009 Nov 10;163(4):1181-91.

[2]Auberson YP, Allgeier H, et al. 5-Phosphonomethylquinoxalinediones as competitive NMDA receptor antagonists with a preference for the human 1A/2A, rather than 1A/2B receptor composition. Bioorg Med Chem Lett. 2002 Apr 8;12(7):1099-102.