PI-3065

产品说明书

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Chemical Structure| 955977-50-1 同义名 : -
CAS号 : 955977-50-1
货号 : A430671
分子式 : C27H31FN6OS
纯度 : 99%+
分子量 : 506.638
MDL号 : MFCD28167771
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(49.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • p110β

    p110β, IC50:1078 nM

  • p110δ

    p110δ, IC50:15 nM
描述 PI-3065 is a selective p110δ inhibitor with IC50 of 15 nM, > 70-fold selectivity over other PI3K family members.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.97mL

0.39mL

0.20mL

9.87mL

1.97mL

0.99mL

19.74mL

3.95mL

1.97mL
参考文献

[1]Bilancio A, Rinaldi B, et al. Inhibition of p110δ PI3K prevents inflammatory response and restenosis after artery injury. Biosci Rep. 2017 Aug 29. pii: BSR20171112.

[2]Ali K, Soond DR, et al. Inactivation of PI(3)K p110δ breaks regulatory T-cell-mediated immune tolerance to cancer. Nature. 2014 Jun 19;510(7505):407-411.