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Gitogenin

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Chemical Structure| 511-96-6 同义名 : NSC 147752;5α-hydroxy Tigogenin;AI3-62266, Digin, Gitogenin
CAS号 : 511-96-6
货号 : A429268
分子式 : C27H44O4
纯度 : 98+%
分子量 : 432.636
MDL号 : MFCD00273328
存储条件:

粉末 Sealed in dry,Room Temperature

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 1.5 mg/mL(3.47 mM),配合低频超声,并水浴加热至45℃助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Gitogenin, a natural product isolated and purified from the herbs of Agave americana, is a selective inhibitor of UGT1A4, and does not inhibit the activities of major human CYP isoforms. Gitogenin is also an inhibitor of enzyme α-glucosidase with IC50 values of 37.2±0.18 and 33.5±0.22 uM, respectively, and shows moderate stimulation of release activity on growth hormone from rat pituitary cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.31mL

0.46mL

0.23mL

11.56mL

2.31mL

1.16mL

23.11mL

4.62mL

2.31mL

参考文献

[1]Naveed MA, Riaz N, et al. Longipetalosides A-C, new steroidal saponins from Tribulus longipetalus. Steroids. 2014 May;83:45-51.

[2]Shim SH, Lee EJ, et al. Rat growth-hormone release stimulators from fenugreek seeds. Chem Biodivers. 2008 Sep;5(9):1753-61.