CAY10602

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Chemical Structure| 374922-43-7 同义名 : -
CAS号 : 374922-43-7
货号 : A424556
分子式 : C22H15FN4O2S
纯度 : 99%+
分子量 : 418.443
MDL号 : MFCD02236691
存储条件：

Pure form Keep in dark place,Inert atmosphere,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 40 mg/mL(95.59 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 CAY10602 is a SIRT1 activator that dose-dependently inhibits the NF-κB-dependent induction of TNF-α by LPS in THP-1 cells at concentrations ranging from 20 to 60 μM. CAY10602 has a significant effect on fat mobilisation in differentiated adipocytes and possesses anti-obesity and/or antidiabetic properties[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.39mL

0.48mL

0.24mL

11.95mL

2.39mL

1.19mL

23.90mL

4.78mL

2.39mL
参考文献

[1]Nayagam VM, et al. SIRT1 modulating compounds from high-throughput screening as anti-inflammatory and insulin-sensitizing agents. J Biomol Screen. 2006 Dec;11(8):959-67.