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Doxofylline

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Chemical Structure| 69975-86-6 同义名 : ABC 12/3;Doxophylline;3;ABC12;DO-309;ALT-07;ABC-1213;ABC-12-3;Ansimar;2-(7'-Theophyllinemethyl)-1,3-dioxolane
CAS号 : 69975-86-6
货号 : A423586
分子式 : C11H14N4O4
纯度 : 99+%
分子量 : 266.253
MDL号 : MFCD00865218
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
靶点

  • PDE
描述 Doxofylline is an orally active inhibitor of phosphodiesterase IV (PDE IV) and an antagonist of the A1 adenosine receptor (A1AR). It is recognized for its anti-inflammatory effects on epithelial cells by inhibiting mitochondrial reactive oxygen species (ROS) production and improving various cellular pathways, such as the NLRP3-TXNIP inflammasome pathway. Doxofylline is particularly relevant for research into asthma, chronic obstructive pulmonary disease (COPD), and bronchospasm[1].[2].[3].
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02522013 Post-dural Puncture Headache Phase 3 Completed - China, Anhui ... 展开 >> Suzhou municipal hospital Suzhou, Anhui, China China, Hebei the second hospital of Hebei medcial university Shijiazhuang, Hebei, China China, Henan Henan Province Hospital of Traditional Chinese Medicine Zhengzhou, Henan, China China, Liaoning Jinzhou central hospital Jinzhou, Liaoning, China 收起 <<
NCT01055041 Moderate to Severe Persistent ... 展开 >>Bronchial Asthma 收起 << Not Applicable Completed - India ... 展开 >> Sir Takthasinhji General Hospital Bhavnagar, Gujarat, India Bhavnagar, Gujarat, India, 364001 收起 <<
NCT03388853 COPD Phase 4 Not yet recruiting March 2019 Turkey ... 展开 >> Cukurova University Faculty of Medicine, Chest Diseases Department Adana, Turkey Health Sciences University, Sureyyapasa Chest Diseases and Thoracic Surgery Training and Research Hospital Istanbul, Turkey 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.76mL

0.75mL

0.38mL

18.78mL

3.76mL

1.88mL

37.56mL

7.51mL

3.76mL
参考文献

[1]Jiao P, et al. The protective effect of doxofylline against lipopolysaccharides (LPS)-induced activation of NLRP3 inflammasome is mediated by SIRT1 in human pulmonary bronchial epithelial cells. Artif Cells Nanomed Biotechnol. 2020 Dec;48(1):687-694.

[2]Riffo-Vasquez Y, et al. Doxofylline, a novofylline inhibits lung inflammation induced by lipopolysacharide in the mouse. Pulm Pharmacol Ther. 2014 Apr;27(2):170-8.

[3]Shukla D, et al. Doxofylline: a promising methylxanthine derivative for the treatment of asthma and chronic obstructive pulmonary disease. Expert Opin Pharmacother. 2009 Oct;10(14):2343-56.