(-)-Norgestrel
产品说明书
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同义名 : | D-(-)-炔诺孕酮 ;D-Norgestrel;Levonorgestrel;Levonorgestrel, Norgestrel, Microval, Postinor, Mirena, Plan B |
| CAS号 : | 797-63-7 | |
| 货号 : | A422801 | |
| 分子式 : | C21H28O2 | |
| 纯度 : | 99+% | |
| 分子量 : | 312.45 | |
| MDL号 : | MFCD00199013 | |
| 存储条件： |
Pure form Sealed in dry,2-8°C In solvent -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 105 mg/mL(336.06 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Levonorgestrel is a synthetic progestogen used as an active ingredient in some hormonal contraceptives. Approximately 20% of levonorgestrel intrauterine system users experience amenorrhea during at least 1 90-day interval by the first year after insertion[3]. Furthermore, when two doses of levonorgestrel 0.75 mg are administered, the second dose can confidently be taken 12-24 hours after the first without compromising efficacy[4]. In addition, the prevalence of adverse events after a levonorgestrel 0.75 mg two-dose regimen and a levonorgestrel 1.5 mg single-dose regimen were not statistically different[5]. Low-dose ethinylestradiol/levonorgestrel 20 microg/100 microg is a combined oral contraceptive that prevents pregnancy primarily by inhibiting ovulation. Ethinylestradiol/levonorgestrel 20 microg/100 microg is well tolerated; adverse events were those commonly associated with combined oral contraceptives[6]. The LNG-IUS (levonorgestrel-releasing intrauterine system) can be used successfully throughout the reproductive period for effective contraception and treatment of menorrhagia[7]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01286948 | Female Contraception | Phase 1 | Completed | - | Chile ... 展开 >> Instituto Chileno de Medicina Reproductiva José Victorino Lastarria 29, Santiago, Chile Dominican Republic Profamilia Socorro Sanchez No. 160, Santo Domingo, Dominican Republic, Apartado Postal 1053 收起 << |
| NCT02545452 | Endometriosis | Phase 1 | Completed | - | Germany ... 展开 >> Berlin, Germany, 13353 收起 << |
| NCT02616146 | Contraception | Phase 3 | Terminated | - | - |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
3.20mL 0.64mL 0.32mL |
16.00mL 3.20mL 1.60mL |
32.01mL 6.40mL 3.20mL |
| 参考文献 |
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