产品说明书
Coenzyme Q10
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同义名 : | CoQ10;Ubiquinone-10;NSC -40665;NSC 140665;Q 199;coenzyme Q;ubiquinone;Vitamin Q;Ubiquinone Q10;NSC 140865;Ubidecarenone |
| CAS号 : | 303-98-0 | |
| 货号 : | A422056 | |
| 分子式 : | C59H90O4 | |
| 纯度 : | 97% | |
| 分子量 : | 863.343 | |
| MDL号 : | MFCD00042919 | |
| 存储条件： |
粉末 Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
无水乙醇: 2.5 mg/mL(2.9 mM)，配合低频超声，并水浴加热至45℃助溶，注意：无水乙醇开封后，易挥发，也会吸收空气中的水分，导致溶解能力下降，请避免使用开封较久的乙醇 DMF: 20 mg/mL(23.17 mM)，配合低频超声，并水浴加热至45℃助溶 |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Coenzyme Q10 (CoQ10) is a vitamin-like substance which functions as an electron carrier within the mitochondrial respiratory chain, as well as serving as an important intracellular antioxidant. Clinical studies have indicated that CoQ10 supplementation may decrease the level of cardiovascular fibrosis to which older individuals are subjected, and thereby improve cardiovascular function and reduce the risk of cardiovascular associated mortality[1]. Coenzyme Q10 is an antioxidant that can target the mechanisms of BC (Breast cancer) tumor progression[2]. Coenzyme Q10 is also used for preventing neurodegeneration against mitochondrial deficiency and oxidative stress[3]. CoQ10 serves as a lipid soluble antioxidant, plays an important role in fatty acid, pyrimidine and lysosomal metabolism, as well as directly mediating the expression of a number of genes, including those involved in inflammation[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01940627 | Oxidative Stress ... 展开 >> Inflammation Muscle Injury 收起 << | Phase 2 Phase 3 | Completed | - | Spain ... 展开 >> Faculty of Sport Sciences Granada, Spain, 18071 收起 << |
| NCT01010711 | Migraine | Not Applicable | Unknown | April 2011 | Germany ... 展开 >> Universiätsklinikum Essen Neurologische Klinik, Westdeutsches Kopfschmerzzentrum, Hufelandstr.26, Recruiting Essen, Nordrhein-Westfalen, Germany, D-45147 Contact: Charly Gaul, MD 0049-201-43696-0 Charly.Gaul@gmx.de Sub-Investigator: Dagny Holle, MD Migräne und Kopfschmerzklinik Königstein Recruiting Königstein Im Taunus, Germany, 61462 Contact: Dr. Jan Brand, Dr. 0049-6174-29040 info@migraene-klinik.de 收起 << |
| NCT01385020 | Healthy Subjects | Phase 4 | Completed | - | Taiwan ... 展开 >> National Taiwan University Hospital Taipei, Taiwan 收起 << |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
1.16mL 0.23mL 0.12mL |
5.79mL 1.16mL 0.58mL |
11.58mL 2.32mL 1.16mL |
| 参考文献 |
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[2]Tafazoli A. Coenzyme Q10 in breast cancer care. Future Oncol. 2017 May;13(11):1035-1041. |