产品说明书
Nirogacestat
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同义名 : | PF-03084014;PF-3084014 |
| CAS号 : | 1290543-63-3 | |
| 货号 : | A421613 | |
| 分子式 : | C27H41F2N5O | |
| 纯度 : | 99%+ | |
| 分子量 : | 489.644 | |
| MDL号 : | MFCD19980705 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,Store in freezer, under -20°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 25 mg/mL(51.06 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Nirogacestat (PF-3084014) functions as an orally available, reversible, non-competitive, and selective inhibitor of γ-secretase, demonstrating an IC50 of 6.2 nM. Its ability to suppress Notch signaling effectively while reducing the risk of gastrointestinal side effects makes it a valuable candidate for the exploration of cancers dependent on Notch receptor activity[1]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
2.04mL 0.41mL 0.20mL |
10.21mL 2.04mL 1.02mL |
20.42mL 4.08mL 2.04mL |
| 参考文献 |
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