AZ6102

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Chemical Structure| 1645286-75-4 同义名 : -
CAS号 : 1645286-75-4
货号 : A421292
分子式 : C25H28N6O
纯度 : 98%
分子量 : 428.529
MDL号 : MFCD28502279
存储条件：

Pure form Keep in dark place,Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 25 mg/mL(58.34 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 AZ6102 is a potent dual inhibitor of TNKS1 and TNKS2, exhibiting IC50 values of 3 nM and 1 nM, respectively. Additionally, AZ6102 demonstrates 100-fold selectivity against other PARP family enzymes, with IC50 values of 2.0 μM, 0.5 μM, and >3 μM for PARP1, PARP2, and PARP6, respectively. Moreover, AZ6102 exhibits inhibition of the Wnt pathway in DLD-1 cells[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.33mL

0.47mL

0.23mL

11.67mL

2.33mL

1.17mL

23.34mL

4.67mL

2.33mL
参考文献

[1]Johannes JW, et al. Pyrimidinone nicotinamide mimetics as selective tankyrase and wnt pathway inhibitors suitable for in vivo pharmacology. ACS Med Chem Lett. 2015 Jan 13;6(3):254-9.