Arctigenin

产品说明书

Print
Chemical Structure| 7770-78-7 同义名 : 牛蒡子苷元 ;(-)-Arctigenin
CAS号 : 7770-78-7
货号 : A420992
分子式 : C21H24O6
纯度 : 98%
分子量 : 372.412
MDL号 : -
存储条件：

Pure form Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(281.95 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Arctigenin is a phenylpropanoid metabolite with antioxidant and anti-inflammatory activities. Arctigenin at 1μM inhibited LPS-induced nuclear NF-κB activation and nuclear translocation of p65, accompanied by inhibition of I-κBα phosphorylation. It inhibited LPS-inducible increase in the iNOS mRNA by 0.01–1μM Arctigenin, with IC50 value<0.01μM for inhibition of the induction of iNOS by LPS[8]. Arctigenin also works as an active adiponectin receptor 1 agonist with IC50 value of 2.6μM for AdipoR1[9]. Arctigenin exerted significant neuroprotective effects on glutamate-injured primary cultures of rat cortical cells by directly binding to kainic acid receptors and partly scavenging of free radicals[10].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.69mL

0.54mL

0.27mL

13.43mL

2.69mL

1.34mL

26.85mL

5.37mL

2.69mL
参考文献

[1]Cho MK, Park JW, et al. Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages. Int Immunopharmacol. 2002 Jan;2(1):105-16.

[2]Sun Y, Zang Z, et al. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354.

[3]Jang YP, Kim SR, et al. Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor. J Neurosci Res. 2002 Apr 15;68(2):233-40.

[4]He B, Zhang HJ, et al. Pharmacokinetics of Arctigenin and Fructus Arctii Powder in Piglets. Front Vet Sci. 2019 Jul 25;6:235.

[5]Wang P, Solorzano W, et al. Arctigenin inhibits prostate tumor cell growth in vitro and in vivo. Clin Nutr Exp. 2017 Jun;13:1-11.

[6]Yang J, Yin HS, et al. Arctigenin Attenuates Ischemia/Reperfusion Induced Ventricular Arrhythmias by Decreasing Oxidative Stress in Rats. Cell Physiol Biochem. 2018;49(2):728-742.

[7]Tan YJ, Ren YS, et al. 28-Day Oral Chronic Toxicity Study of Arctigenin in Rats. Front Pharmacol. 2018 Sep 26;9:1077.

[8]Cho MK, Park JW, Jang YP, Kim YC, Kim SG. Potent inhibition of lipopolysaccharide-inducible nitric oxide synthase expression by dibenzylbutyrolactone lignans through inhibition of I-kappaBalpha phosphorylation and of p65 nuclear translocation in macrophages. Int Immunopharmacol. 2002 Jan;2(1):105-16. doi: 10.1016/s1567-5769(01)00153-9. PMID: 11789661.

[9]Sun Y, Zang Z, Zhong L, Wu M, Su Q, Gao X, Zan W, Lin D, Zhao Y, Zhang Z. Identification of adiponectin receptor agonist utilizing a fluorescence polarization based high throughput assay. PLoS One. 2013 May 14;8(5):e63354. doi: 10.1371/journal.pone.0063354. PMID: 23691032; PMCID: PMC3653934.

[10]Jang YP, Kim SR, Choi YH, Kim J, Kim SG, Markelonis GJ, Oh TH, Kim YC. Arctigenin protects cultured cortical neurons from glutamate-induced neurodegeneration by binding to kainate receptor. J Neurosci Res. 2002 Apr 15;68(2):233-40. doi: 10.1002/jnr.10204. PMID: 11948668.