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α-Lapachone

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Chemical Structure| 4707-33-9 同义名 : alpha-Lapachone
CAS号 : 4707-33-9
货号 : A418258
分子式 : C15H14O3
纯度 : 99%+
分子量 : 242.27
MDL号 : MFCD00022287
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(433.4 mM)，配合低频超声，并水浴加热至45℃助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 alpha-Lapachone, a natural product isolated and purified from the barks of Catalpa ovata, does not induce H₂O₂ formmation but shows an approximately the same trypanocidal activity of beta-lapachone.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

4.13mL

0.83mL

0.41mL

20.64mL

4.13mL

2.06mL

41.28mL

8.26mL

4.13mL
参考文献

[1]Du L, Li MD, et al. Photoconversion of β-Lapachone to α-Lapachone via a Protonation-Assisted Singlet Excited State Pathway in Aqueous Solution: A Time-Resolved Spectroscopic Study. J Org Chem. 2015 Aug 7;80(15):7340-50.

[2]Salustiano EJ, Netto CD, et al. Comparison of the cytotoxic effect of lapachol, alpha-lapachone and pentacyclic 1,4-naphthoquinones on human leukemic cells. Invest New Drugs. 2010 Apr;28(2):139-44.