Reversine

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Chemical Structure| 656820-32-5 同义名 : -
CAS号 : 656820-32-5
货号 : A418002
分子式 : C21H27N7O
纯度 : 98%
分子量 : 393.485
MDL号 : -
存储条件：

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 18 mg/mL(45.75 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • Aurora A

    Aurora A, IC50:12 nM

  • Aurora B

    Aurora B, IC50:13 nM

  • Aurora C

    Aurora C, IC50:20 nM

  • Adenosine Receptor

    human A3 adenosine receptor, Ki:0.66 μM
描述 Reversine, an innovative inhibitor of Aurora kinases, prevents colony formation in human acute myeloid leukemia cells. It strongly inhibits Aurora kinases A and B and moderately inhibits Aurora kinase C at a concentration of 0.5 μM. In further testing, Reversine shows an IC50 of 400 nM for Aurora kinase A, 500 nM for B, and 400 nM for C, while showing limited inhibition on other tested kinases. Additionally, the IC50 for MEK1 is >1.5 μM and for muscle myosin is 350 nM[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.54mL

0.51mL

0.25mL

12.71mL

2.54mL

1.27mL

25.41mL

5.08mL

2.54mL
参考文献

[1]Morejohn LC, et al. Oryzalin, a dinitroaniline herbicide, binds to plant tubulin and inhibits microtubule polymerization in vitro. Planta. 1987 Oct;172(2):252-64.