产品说明书

Ibiglustat

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Chemical Structure| 1401090-53-6 同义名 : Venglustat;SAR402671;GZ/SAR402671;Genz-682452;GZ402671
CAS号 : 1401090-53-6
货号 : A417980
分子式 : C20H24FN3O2S
纯度 : 99%+
分子量 : 389.487
MDL号 : MFCD28502073
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(128.37 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Ibiglustat is a potent and selective glucosylceramide synthase inhibitor and ceramide glucosyltransferase inhibitor.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.84mL

2.57mL

1.28mL

25.67mL

5.13mL

2.57mL
参考文献

[1]Jarnes Utz JR, Kim S, et al. Infantile gangliosidoses: Mapping a timeline of clinical changes. Mol Genet Metab. 2017 Apr 29. pii: S1096-7192(17)30112-9.

[2]Bountouvi E, Papadopoulou A, et al. Novel NPC1 mutations with different segregation in two related Greek patients with Niemann-Pick type C disease: molecular study in the extended pedigree and clinical correlations. BMC Med Genet. 2017 May 4;18(1):51.