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Edoxaban tosylate

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Chemical Structure| 480449-71-6 同义名 : DU-176b;Edoxaban (tosylate)
CAS号 : 480449-71-6
货号 : A415948
分子式 : C31H38ClN7O7S2
纯度 : 98%
分子量 : 720.259
MDL号 : MFCD16038915
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(69.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Edoxaban is an oral factor Xa (FXa) inhibitor in clinical development for stroke prevention.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT01802775 Peripheral Arterial Disease Phase 2 Completed - -
NCT01802775 - Completed - -
NCT02047565 Bleeding Phase 1 Completed - United States, Kansas ... 展开 >> Quintiles Overland Park, Kansas, United States, 66211 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.39mL

0.28mL

0.14mL

6.94mL

1.39mL

0.69mL

13.88mL

2.78mL

1.39mL
参考文献

[1]Mendell J, Noveck RJ, et al. Pharmacokinetics of the direct factor Xa inhibitor edoxaban and digoxin administered alone and in combination. J Cardiovasc Pharmacol. 2012 Oct;60(4):335-41.

[2]Mendell J, Lee F, et al. The effects of the antiplatelet agents, aspirin and naproxen, on pharmacokinetics and pharmacodynamics of the anticoagulant edoxaban, a direct factor Xa inhibitor. J Cardiovasc Pharmacol. 2013 Aug;62(2):212-21.