Aurothioglucose

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Chemical Structure| 12192-57-3 同义名 : Gold thioglucose
CAS号 : 12192-57-3
货号 : A415173
分子式 : C6H11AuO5S
纯度 : 98+%
分子量 : 392.18
MDL号 : MFCD00056080
存储条件:

Pure form Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 5 mg/mL(12.75 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 120 mg/mL(305.98 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Aurothioglucose is a well known active-site inhibitor of TrxR1, inhibited TrxR1 activity in HeLa cell cytosol but had no effect on the viability of the cells.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.55mL

0.51mL

0.25mL

12.75mL

2.55mL

1.27mL

25.50mL

5.10mL

2.55mL

参考文献

[1]Britt RD Jr, Velten M, et al. The thioredoxin reductase-1 inhibitor aurothioglucose attenuates lung injury and improves survival in a murine model of acute respiratory distress syndrome. Antioxid Redox Signal. 2014 Jun 10;20(17):2681-91.

[2]Watson WH, Heilman JM, et al. Thioredoxin reductase-1 knock down does not result in thioredoxin-1 oxidation. Biochem Biophys Res Commun. 2008 Apr 11;368(3):832-6.