产品说明书

Golgicide A

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Chemical Structure| 1139889-93-2 同义名 : GCA
CAS号 : 1139889-93-2
货号 : A414566
分子式 : C17H14F2N2
纯度 : 99%+
分子量 : 284.303
MDL号 : MFCD27937048
存储条件：

粉末 Sealed in dry,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(369.32 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
靶点

  • ATPase
描述 Golgicide A serves as a powerful, highly selective, and reversible antagonist of GBF1, which is an ADP-ribosylation factor guanine nucleotide exchange factor (ArfGEF) associated with the cis-Golgi. It works as a strong and highly efficient inhibitor of shiga toxin's action. It effectively blocks the impact of shiga toxin on protein synthesis, exhibiting an IC50 value of 3.3 μM[1]. Golgicide A significantly inhibits the replication of coxsackievirus B3 (CVB3) as well as other types of human enteroviruses[2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.59mL

3.52mL

1.76mL

35.17mL

7.03mL

3.52mL
参考文献

[1]Sáenz JB, et al. Golgicide A reveals essential roles for GBF1 in Golgi assembly and function. Nat Chem Biol. 2009 Mar;5(3):157-65.

[2]van der Linden L, et al. Differential effects of the putative GBF1 inhibitors Golgicide A and AG1478 on enterovirus replication. J Virol. 2010 Aug;84(15):7535-42.