产品说明书
Willardiine
 |
同义名 : | (-)-Willardiine |
| CAS号 : | 21416-43-3 | |
| 货号 : | A412916 | |
| 分子式 : | C7H9N3O4 | |
| 纯度 : | 98% | |
| 分子量 : | 199.164 | |
| MDL号 : | MFCD00153879 | |
| 存储条件： |
粉末 Keep in dark place,Sealed in dry,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : | - | |
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | (S) -Willardiine is a potent agonist of AMPA/kainate receptors with EC50 of 44.8 uM. Willardiines produce strikingly different degrees of desensitization: at saturating doses the equilibrium response to the weakly desensitizing agonist (S)-5-iodowillardiine was similar in amplitude to the response to kainate and 10 times larger than the response to the strongly desensitizing agonist (S)-willardiine[3]. In newborn mice (P5, histopathology at P10), local injection of the AMPA receptor agonist S-bromo-willardiine at day 5 after birth induced cortical damage and white matter damage, which was reduced in a dose-dependent manner by the AMPA receptor antagonists[4]. At a concentration of 1.8 mM, Ca2+ inhibited the currents induced by 100 microM willardiine by approximately 50%. Ca2+ inhibition of the willardiine-induced response is concentration dependent[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
5.02mL 1.00mL 0.50mL |
25.10mL 5.02mL 2.51mL |
50.21mL 10.04mL 5.02mL |
| 参考文献 |
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