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(R)-(+)-Bay-K-8644

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Chemical Structure| 98791-67-4 同义名 : NI 105;R 4407
CAS号 : 98791-67-4
货号 : A410149
分子式 : C16H15F3N2O4
纯度 : 98%
分子量 : 356.296
MDL号 : MFCD00153768
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 300 mg/mL(841.99 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Bay-K-8644 (R)-(+)- is a calcium channel inhibitor. Bay-K-8644 (R)-(+)- inhibits Ba2+ currents (IBa) (IC50=975 nM).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.81mL

0.56mL

0.28mL

14.03mL

2.81mL

1.40mL

28.07mL

5.61mL

2.81mL
参考文献

[1]Sidaway P, Teramoto N. L-type Ca2+ channel sparklets revealed by TIRF microscopy in mouse urinary bladder smooth muscle. PLoS One. 2014 Apr 3;9(4):e93803. doi: 10.1371/journal.pone.0093803. eCollection 2014.

[2]Zhu HL, Teramoto N. Antagonistic actions of S(-)-Bay K 8644 on cyclic nucleotide-induced inhibition of voltage-dependent Ba(2+) currents in guinea pig gastric antrum. Naunyn Schmiedebergs Arch Pharmacol. 2008 Dec;378(6):609-15.