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Sepantronium HCl

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Chemical Structure| 355406-09-6 同义名 : YM-155 hydrochloride;YM-155 (chloride);YM-155;YM-155 chloride;YM-155 Cl;Sepantronium hydrochloride
CAS号 : 355406-09-6
货号 : A404855
分子式 : C20H19ClN4O3
纯度 : 99+%
分子量 : 398.843
MDL号 : MFCD18207200
存储条件：

粉末 Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 YM155 hydrochloride is a potent survivin suppressant by inhibiting Survivin promoter activity with IC50 of 0.54 nM.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.51mL

0.50mL

0.25mL

12.54mL

2.51mL

1.25mL

25.07mL

5.01mL

2.51mL
参考文献

[1]Iwasa T, Okamoto I, et al. Radiosensitizing effect of YM155, a novel small-molecule survivin suppressant, in non-small cell lung cancer cell lines. Clin Cancer Res. 2008 Oct 15;14(20):6496-504.

[2]Nakahara T, Kita A, et al. YM155, a novel small-molecule survivin suppressant, induces regression of established human hormone-refractory prostate tumor xenografts. Cancer Res. 2007 Sep 1;67(17):8014-21.