产品说明书

NB-598 hydrochloride

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Chemical Structure| 136719-25-0 同义名 : -
CAS号 : 136719-25-0
货号 : A403797
分子式 : C27H32ClNOS2
纯度 : 98+%
分子量 : 486.13
MDL号 : -
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 : -
动物实验配方：
生物活性
描述 NB-598 is a potent competitive inhibitor of squalene epoxidase (SE).
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.06mL

0.41mL

0.21mL

10.29mL

2.06mL

1.03mL

20.57mL

4.11mL

2.06mL
参考文献

[1]Xia F, Xie L, et al. Inhibition of cholesterol biosynthesis impairs insulin secretion and voltage-gated calcium channel function in pancreatic beta-cells. Endocrinology. 2008 Oct;149(10):5136-45.

[2]Horie M, Iwasawa Y, et al. Effects of NB-598, a potent squalene epoxidase inhibitor, on the apical membrane uptake of cholesterol and basolateral membrane secretion of lipids in Caco-2 cells. Biochem Pharmacol. 1993 Jul 20;46(2):297-305.