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Eltanexor Z-isomer

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Chemical Structure| 1642300-78-4 同义名 : KPT-8602 (Z-isomer)
CAS号 : 1642300-78-4
货号 : A403553
分子式 : C17H10F6N6O
纯度 : 98+%
分子量 : 428.291
MDL号 : -
存储条件：

粉末

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 50 mg/mL(116.74 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 KPT-8602 Z-isomer is an isomer of KPT-8602, which is highly specific for XPO1 inhibition and demonstrates potent anti-leukemic activity.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.33mL

0.47mL

0.23mL

11.67mL

2.33mL

1.17mL

23.35mL

4.67mL

2.33mL
参考文献

[1]Vercruysse T, De Bie J, et al. The Second-Generation Exportin-1 Inhibitor KPT-8602 Demonstrates Potent Activity against Acute Lymphoblastic Leukemia. Clin Cancer Res. 2017 May 15;23(10):2528-2541.

[2]Hing ZA, Fung HY, et al. Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies. Leukemia. 2016 Dec;30(12):2364-2372.