产品说明书

SBC-115076

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Chemical Structure| 489415-96-5 同义名 : -
CAS号 : 489415-96-5
货号 : A402455
分子式 : C31H33N3O5
纯度 : 99%+
分子量 : 527.611
MDL号 : MFCD03296540
存储条件：

粉末 Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(199.01 mM)，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：

5% DMSO+45% PEG 300+water 7 mg/mL

生物活性
描述 SBC-115076 is a powerful inhibitor of proprotein convertase subtilisin/kexin type 9 (PCSK9). PCSK9, a proprotein convertase, is pivotal in the metabolism of LDL receptors[1][2].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

1.90mL

0.38mL

0.19mL

9.48mL

1.90mL

0.95mL

18.95mL

3.79mL

1.90mL
参考文献

[1]Chanisa Thonusin, et al. The comparative effects of high dose atorvastatin and proprotein convertase subtilisin/kexin type 9 inhibitor on the mitochondria of oxidative muscle fibers in obese-insulin resistant female rats. Toxicol Appl Pharmacol. 2019 Nov 1;382:114741.

[2]Wiciński M, et al. PCSK9 signaling pathways and their potential importance in clinical practice. EPMA J. 2017;8(4):391-402. Published 2017 Aug 14.