Jujuboside A

产品说明书

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Chemical Structure| 55466-04-1 同义名 : -
CAS号 : 55466-04-1
货号 : A402358
分子式 : C58H94O26
纯度 : 98%
分子量 : 1207.351
MDL号 : MFCD03427709
存储条件:

Pure form Keep in dark place,Inert atmosphere,2-8°C

In solvent -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(86.97 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

H2O: 50 mg/mL(41.41 mM),配合低频超声助溶

动物实验配方:
生物活性
描述 Jujuboside A, a natural product isolated and purified from the seeds of Zizyphus jujuba with neurophysiological inhibitory effects, performs its specific sedative and hypnotic effect through not only adjusting GABA receptors subunit mRNAs expression, but also down-regulating the secretion of relevant inflammation cytokines on the intestinal mucosal system to affect the intercellular cytokine network between nerve cells in the brain and may serve as a potential therapeutic agent for the treatment of Alzheimer׳s disease.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

0.83mL

0.17mL

0.08mL

4.14mL

0.83mL

0.41mL

8.28mL

1.66mL

0.83mL

参考文献

[1]Liu Z, Zhao X, et al. Jujuboside A, a neuroprotective agent from semen Ziziphi Spinosae ameliorates behavioral disorders of the dementia mouse model induced by Aβ 1-42. Eur J Pharmacol. 2014 Sep 5;738:206-13.

[2]Wang X, Yang B, et al. Potential drug targets on insomnia and intervention effects of Jujuboside A through metabolic pathway analysis as revealed by UPLC/ESI-SYNAPT-HDMS coupled with pattern recognition approach. J Proteomics. 2012 Feb 2;75(4):1411-27.