Avibactam free acid

产品说明书

Print
Chemical Structure| 1192500-31-4 同义名 : NXL-104 free acid;Avibactam(free acid)
CAS号 : 1192500-31-4
货号 : A400735
分子式 : C7H11N3O6S
纯度 : 98%
分子量 : 265.244
MDL号 : MFCD30478396
存储条件：

Pure form Keep in dark place,Sealed in dry,Store in freezer, under -20°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 120 mg/mL(452.41 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Avibactam free acid is a covalent, reversible β-lactamase inhibitor, and inhibits β-lactamase TEM-1 and CTX-M-15 with IC50 of 8 nM and 5 nM, respectively.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.77mL

0.75mL

0.38mL

18.85mL

3.77mL

1.89mL

37.70mL

7.54mL

3.77mL
参考文献

[1]Ehmann DE, Jahić H, et al. Avibactam is a covalent, reversible, non-β-lactam β-lactamase inhibitor. Proc Natl Acad Sci U S A. 2012 Jul 17;109(29):11663-8.

[2]Livermore DM, Mushtaq S, et al. Characterization of β-lactamase and porin mutants of Enterobacteriaceae selected with ceftaroline + avibactam (NXL104). J Antimicrob Chemother. 2012 Jun;67(6):1354-8.