产品说明书

Deoxyandrographolide

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Chemical Structure| 79233-15-1 同义名 : -
CAS号 : 79233-15-1
货号 : A400457
分子式 : C20H30O4
纯度 : 98%
分子量 : 334.45
MDL号 : MFCD03093713
存储条件:

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月

溶解度 :

DMSO: 105 mg/mL(313.95 mM),配合低频超声助溶,注意:DMSO长时间开封后,会吸水并导致溶解能力下降,请避免使用长期开封的DMSO

动物实验配方:
生物活性
描述 Deoxyandrographolide is a natural compound extracted from the herbs of Andrographis paniculata (Burm. f.) Nees, promotes glucose uptake through glucose transporter-4 translocation to plasma membrane in L6 myotubes and exerts antihyperglycemic effect in vivo.
临床研究
NCT号 适应症或疾病 临床期 招募状态 预计完成时间 地点
NCT02273635 Primary Progressive Multiple S... 展开 >>clerosis Multiple Sclerosis, Secondary Progressive 收起 << Phase 1 Phase 2 Unknown April 2017 Chile ... 展开 >> Multiple Sclerosis Centre, Pontificia Universidad Catolica de Chile Recruiting Santiago, Metropolitana, Chile, 8330033 Contact: Claudia A Carcamo, MD, PhD.    56 2 3546885    ccarcamo@med.puc.cl    Contact: Ana C Reyes, Nurse    56 2 3546885    acreyes@med.puc.cl 收起 <<
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.99mL

0.60mL

0.30mL

14.95mL

2.99mL

1.49mL

29.90mL

5.98mL

2.99mL

参考文献

[1]Mandal S, Mukhopadhyay S, et al. 14-Deoxyandrographolide alleviates ethanol-induced hepatosteatosis through stimulation of AMP-activated protein kinase activity in rats. Alcohol. 2014 Mar;48(2):123-32.

[2]Roy DN, Mandal S, et al. 14-Deoxyandrographolide desensitizes hepatocytes to tumour necrosis factor-alpha-induced apoptosis through calcium-dependent tumour necrosis factor receptor superfamily member 1A release via the NO/cGMP pathway. Br J Pharmacol. 2010 Aug;160(7):1823-43.