Iproniazid
产品说明书
 |
同义名 : | N'-异丙基吡啶-4-酰肼 ;Marsilid;Iprazid |
| CAS号 : | 54-92-2 | |
| 货号 : | A399744 | |
| 分子式 : | C9H13N3O | |
| 纯度 : | 98%+ | |
| 分子量 : | 179.219 | |
| MDL号 : | MFCD00153819 | |
| 存储条件： |
Pure form Keep in dark place,Inert atmosphere,Room temperature In solvent -20°C:3-6个月-80°C:12个月 |
|
| 溶解度 : |
DMSO: 105 mg/mL(585.88 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO H2O: 100 mg/mL(557.98 mM) |
|
| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Iproniazid is a non-selective, irreversible monoamine oxidase (MAO) inhibitor of the hydrazine class. Iproniazid has antidepressive activity[1]. Iproniazid, which inhibits monoamine oxidase but not prostacyclin synthesis, failed to enhance platelet aggregation[2]. Iproniazid was found to inhibit formalin-induced oedema of the foot, dextran-induced oedema and cotton-pellet-induced granulomatous tissue in the rat[3]. 5-Hydroxytryptamine can interrupt pregnancy at all stages in mice but is particularly effective early and late in pregnancy. Iproniazid exerts its action essentially in the first half of pregnancy. 5-Hydroxytryptamine produces striking hemorrhage in the placenta[4]. Chronic glucocorticoid treatment may have a slight inhibitory effect on brain MAO and also has the ability to partially reverse or antagonize the inhibition of MAO caused by iproniazid[5]. Rats were bilaterally ovariectomized on Day 3 post coitum and treated daily with progesterone. Iproniazid, an inhibitor of monoamine oxidase, on Day 8 induced implantation in all rats[6]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
|
1 mM 5 mM 10 mM |
5.58mL 1.12mL 0.56mL |
27.90mL 5.58mL 2.79mL |
55.80mL 11.16mL 5.58mL |
| 参考文献 |
|---|