产品说明书
2-Thiouracil
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同义名 : | 硫代由雪 ;Thiouracil;Antagothyroil;NSC 290414;NSC 290413;NSC 290412;NSC 19473 |
| CAS号 : | 141-90-2 | |
| 货号 : | A399147 | |
| 分子式 : | C4H4N2OS | |
| 纯度 : | 97% | |
| 分子量 : | 128.152 | |
| MDL号 : | MFCD00006039 | |
| 存储条件： |
粉末 Inert atmosphere,Room Temperature 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 50 mg/mL(390.16 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | 2-Thiouracil (Thiouracil) is an antithyroid compound. 2-Thiouracil is a selective inhibitor of neuronal nitric oxide synthase (nNOS) with a Ki of 20 μM. The drug apparently interfered with the substrate- and tetrahydrobiopterin (BH(4))-binding to the enzyme. It caused a 60% inhibition of H(2)O(2) production in the absence of L-arginine and BH(4), and antagonised BH(4)-induced dimerisation of nNOS, but did not affect cytochrome c reduction[3]. 2-thiouridine (alone or within an RNA chain) is predominantly transformed under oxidative stress conditions to 4-pyrimidinone riboside (H2U) and not to uridine. 2-Thiouracil-containing nucleosides are essential modified units of natural and synthetic nucleic acids[4]. 2-thiouracil could not inhibit the synthesis of TMV (tobacco mosaic virus) RNA, but could inhibit some early functions of TMV. 1 mM 2-thiouracil inhibited viral protein and RNA synthesis totally when treatment began within the first 4 h after initiation of replication, but not at all when treatment began at 12 h or later[5]. | ||
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
7.80mL 1.56mL 0.78mL |
39.02mL 7.80mL 3.90mL |
78.03mL 15.61mL 7.80mL |
| 参考文献 |
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