MBCQ

产品说明书

Print
Chemical Structure| 150450-53-6 同义名 : -
CAS号 : 150450-53-6
货号 : A395789
分子式 : C16H12ClN3O2
纯度 : 99%+
分子量 : 313.738
MDL号 : -
存储条件：

Pure form Sealed in dry,2-8°C

In solvent -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(334.67 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 MBCQ is a potent, selective inhibitor of cGMP-specific phosphodiesterase (PDE5) with an IC50 value of 19 nM. MBCQ lacks inhibitory activity against other PDE isozymes (all IC50s >100 μM). MBCQ dilates coronary arteries through specific inhibition of cGMP-PDE[1][2][3].MBCQ induces relaxation of constricted isolated porcine coronary arteries induced by PGF2α pretreatment, with an EC50 value of 190 nM[1][2][3].Acting for 10 minutes at a concentration range of less than 10 μM, MBCQ inhibited carbachol (10 μM)-induced contraction of rat ileal smooth muscle in a concentration-dependent manner[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.19mL

0.64mL

0.32mL

15.94mL

3.19mL

1.59mL

31.87mL

6.37mL

3.19mL
参考文献

[1]Y Takase, et al. Cyclic GMP phosphodiesterase inhibitors. 2. Requirement of 6-substitution of quinazoline derivatives for potent and selective inhibitory activity. J Med Chem. 1994 Jun 24;37(13):2106-11.

[2]Jeffery D MacPherson, et al. Inhibition of phosphodiesterase 5 selectively reverses nitrate tolerance in the venous circulation J Pharmacol Exp Ther. 2006 Apr;317(1):188-95.

[3]Takeharu Kaneda, et al. Lack of cyclic nucleotide regulation of MBCQ-induced relaxation of rat ileal smooth muscle. J Smooth Muscle Res. 2003 Jun;39(3):47-54.