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R-IMPP

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Chemical Structure| 2133832-83-2 同义名 : PF-00932239
CAS号 : 2133832-83-2
货号 : A395105
分子式 : C24H27N3O2
纯度 : 99%+
分子量 : 389.49
MDL号 : MFCD31544323
存储条件：

粉末 Keep in dark place,Inert atmosphere,2-8°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(269.58 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 R-IMPP is a PCSK9 secretion inhibitor with an IC50 value of 4.8 μM, targeting the 80S ribosome to inhibit PCSK9 protein translation. R-IMPP stimulates the uptake of LDL-C in hepatocellular carcinoma cells by increasing LDL-R levels, without altering the levels of secreted transferrin. R-IMPP does not reduce PCSK9 transcription or increase PCSK9 degradation but leads to transcription-dependent inhibition of PCSK9 translation. R-IMPP can selectively bind to human ribosomes but not to E. coli ribosomes[1].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.57mL

0.51mL

0.26mL

12.84mL

2.57mL

1.28mL

25.67mL

5.13mL

2.57mL
参考文献

[1]Petersen DN, et al. A Small-Molecule Anti-secretagogue of PCSK9 Targets the 80S Ribosome to Inhibit PCSK9 Protein Translation. Cell Chem Biol. 2016 Nov 17;23(11):1362-1371