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Strictosamide

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Chemical Structure| 23141-25-5 同义名 : -
CAS号 : 23141-25-5
货号 : A395018
分子式 : C26H30N2O8
纯度 : 98%
分子量 : 498.525
MDL号 : MFCD14105616
存储条件：

粉末 Inert atmosphere,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(210.62 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 Strictosamide, a natural product isolated and purified from the herbs of Nauclea latifolia, may have important effects on inflammation and inflammatory pain, shows slightly toxicity to Charles River mouse (LD(50)=723.17 mg/kg), producing CNS depression and kidney toxicity, and has nonsignificant in vitro and in vivo effect on kidney Na(+),K(+)-ATPase activity but produced an in vivo increase of Na(+),K(+)-ATPase activity of brain.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

2.01mL

0.40mL

0.20mL

10.03mL

2.01mL

1.00mL

20.06mL

4.01mL

2.01mL
参考文献

[1]Li Z, Li Z, et al. Synthesis and Biological Evaluation of Strictosamide Derivatives with Improved Antiviral and Antiproliferative Activities. Chem Biol Drug Des. 2015 Oct;86(4):523-30.

[2]Li N, Cao L, et al. In vivo anti-inflammatory and analgesic activities of strictosamide from Nauclea officinalis. Pharm Biol. 2014 Nov;52(11):1445-50.