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5,7-Dihydroxychromone

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Chemical Structure| 31721-94-5 同义名 : 5,7-二羟基色原酮 ;DHC
CAS号 : 31721-94-5
货号 : A390989
分子式 : C9H6O4
纯度 : 98%
分子量 : 178.142
MDL号 : MFCD14583153
存储条件：

粉末 Keep in dark place,Sealed in dry,Store in freezer, under -20°C

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 105 mg/mL(589.42 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 5,7-Dihydroxychromone, a natural product isolated and purified from the bark of Garcinia cambogia., exerts neuroprotective effect against 6-OHDA-induced oxidative stress and apoptosis by activating Nrf2/ARE signal, and induces the translocation of Nrf2 to the nucleus and increases Nrf2/ARE binding activity which results in the up-regulation of the expression of Nrf2-dependent antioxidant genes, including HO-1, NQO1, and GCLc.
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

5.61mL

1.12mL

0.56mL

28.07mL

5.61mL

2.81mL

56.13mL

11.23mL

5.61mL
参考文献

[1]Kim DW, Lee KT, et al. Neuroprotection against 6-OHDA-induced oxidative stress and apoptosis in SH-SY5Y cells by 5,7-Dihydroxychromone: Activation of the Nrf2/ARE pathway. Life Sci. 2015 Jun 1;130:25-30.

[2]Koo HJ, Kwak JH, Kang SC. Anti-diabetic properties of Daphniphyllum macropodum fruit and its active compound. Biosci Biotechnol Biochem. 2014;78(8):1392-401.