产品说明书
Esomeprazole
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同义名 : | (S)-Omeprazole;(-)-Omeprazole;(–)-Omeprazole |
| CAS号 : | 119141-88-7 | |
| 货号 : | A388173 | |
| 分子式 : | C17H19N3O3S | |
| 纯度 : | 99% | |
| 分子量 : | 345.42 | |
| MDL号 : | MFCD09907604 | |
| 存储条件： |
粉末 Keep in dark place,Inert atmosphere,2-8°C 液体 -20°C:3-6个月-80°C:12个月 |
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| 溶解度 : |
DMSO: 120 mg/mL(347.4 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO |
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| 动物实验配方： |
| 生物活性 | |||
|---|---|---|---|
| 描述 | Proton pump inhibitors (PPIs) are one of the most prescribed class of drugs today and are used for patients with an array of gastroenterological conditions that include gastroesophageal reflux, peptic ulcer disease, Helicobacter pylori infection, and Barrett's esophagus[3]. Esomeprazole, a new proton pump inhibitor, is the S-isomer of omeprazole and is the first such inhibitor to be developed as a single isomer. Esomeprazole provided better control of intragastric pH than omeprazole, lansoprazole and pantoprazole in trials conducted in patients with gastro-oesophageal reflux disease (GORD) or healthy volunteers (n = 20 to 115). In 2 large randomised, double-blind multicentre trials, esomeprazole 20 and/or 40mg for 8 weeks produced higher healing rates of erosive oesophagitis and better symptom control than omeprazole 20 mg in patients with GORD[4]. | ||
| 临床研究 | |||||
|---|---|---|---|---|---|
| NCT号 | 适应症或疾病 | 临床期 | 招募状态 | 预计完成时间 | 地点 |
| NCT01205230 | Cancer | Phase 4 | Completed | - | United States, New Jersey ... 展开 >> GSK Investigational Site New Brunswick, New Jersey, United States, 08901 United States, South Carolina GSK Investigational Site Greenville, South Carolina, United States, 29605 收起 << |
| NCT00352261 | Barrett's Esophagus | Phase 4 | Completed | - | United States, Arizona ... 展开 >> Research Site Phoenix, Arizona, United States Research Site Tucson, Arizona, United States United States, Illinois Research Site North Chicago, Illinois, United States United States, Minnesota Research Site Rochester, Minnesota, United States United States, Missouri Research Site Kansas City, Missouri, United States Research SIte Springfield, Missouri, United States United States, Montana Research Site Butte, Montana, United States United States, Ohio Research Site Cleveland, Ohio, United States United States, Pennsylvania Research Site Philadelphia, Pennsylvania, United States United States, Tennessee Research Site Knoxville, Tennessee, United States United States, Texas Research Site Dallas, Texas, United States United States, Virginia Research Site Norfolk, Virginia, United States 收起 << |
| NCT01205230 | - | Completed | - | - | |
| 实验方案 | |||
|---|---|---|---|
| 1mg | 5mg | 10mg | |
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1 mM 5 mM 10 mM |
2.90mL 0.58mL 0.29mL |
14.48mL 2.90mL 1.45mL |
28.95mL 5.79mL 2.90mL |
| 参考文献 |
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