产品说明书

MBX2329

Print
Chemical Structure| 1438272-42-4 同义名 : -
CAS号 : 1438272-42-4
货号 : A388120
分子式 : C16H26ClNO
纯度 : 99%+
分子量 : 283.837
MDL号 : MFCD31812403
存储条件：

粉末 Inert atmosphere,Room Temperature

液体 -20°C:3-6个月-80°C:12个月
溶解度 :

DMSO: 250 mg/mL(880.79 mM)，配合低频超声助溶，注意：DMSO长时间开封后，会吸水并导致溶解能力下降，请避免使用长期开封的DMSO
动物实验配方：
生物活性
描述 The therapeutic options for influenza are limited due to the emergence of drug-resistant virus strains. The influenza virus glycoprotein hemagglutinin (HA) plays a critical role in virus infection. MBX2329 is a small-molecule inhibitor targeting HA-mediated viral entry. MBX2329 showed concentration-dependent inhibitory activity against HIV/HA(H5) with an IC90 value of 8.6μM. MBX2329 displayed little inhibitory activity against HIV/LASV-GP, HIV/EBOV-GP, and HIV/VSV-G with IC90 values above >100 μM. MBX2329 inhibited influenza A H1N1 virus strains A/PR/8/34 (H1N1), A/Florida/21/2008 (H1N1-H275Y), A/Washington/10/2008 (H1N1), and A/California/10/2009 (H1N1) with IC50 values of 0.29–0.53μM. It also inhibited HPAI H5N1 virus strain A/Hong Kong/H5N1 with an IC50 value of 5.9μM. MBX2329 inhibited acid-induced hemolysis in a concentration-dependent manner with an IC50 value of 2.1μM[3].
实验方案
1mg 5mg 10mg

1 mM

5 mM

10 mM

3.52mL

0.70mL

0.35mL

17.62mL

3.52mL

1.76mL

35.23mL

7.05mL

3.52mL
参考文献

[1]Guan S, Wang T, et al. Exploration of binding and inhibition mechanism of a small molecule inhibitor of influenza virus H1N1 hemagglutinin by molecular dynamics simulation. Sci Rep. 2017 Jun 19;7(1):3786.

[2]Antanasijevic A, Basu A, et al. Mutagenesis studies of the H5 influenza hemagglutinin stem loop region. J Biol Chem. 2014 Aug 8;289(32):22237-45.

[3]Basu A, Antanasijevic A, Wang M, Li B, Mills DM, Ames JA, Nash PJ, Williams JD, Peet NP, Moir DT, Prichard MN, Keith KA, Barnard DL, Caffrey M, Rong L, Bowlin TL. New small molecule entry inhibitors targeting hemagglutinin-mediated influenza a virus fusion. J Virol. 2014 Feb;88(3):1447-60.